Graham Potter's men finished an impressive ninth last season but have lost influential midfielder Yves Bissouma, who joined Antonio Conte's Tottenham for £30m earlier this window.
Marc Cucurella also departed as he joined Chelsea last Thursday in a £60m switch. It's a huge blow for Potter
Erik ten Hag will get his first feel of Premier League football at Old Trafford today. His pre-season has largely been dominated by the future of Cristiano Ronaldo. His star striker is however expected to feature at some stage today, due to an injury to his teammate Anthony Martial.
Leicester, Brentford, West Ham and champions Manchester City also get their campaigns underway today.
Here, the stats gurus at FiveThirtyEight have predicted how the Premier League will finish – who will stay-up, win the title and seal those all-important European spots